Applications of Electronic Cryomicroscopy in Production of Vaccines against SARS-CoV-2

Abstract

This essay aims to discuss models of SARS-CoV-2 vaccine proposals using Cryo-TEM techniques. It is based on ideas Humberto Fernández Morán;when he said, “time has come for biomolecules”, his Electronic Cryomicroscopy Transmission, (Cryo-TEM), went from being a cumbersome and descriptive technique to being easy, structural and more appropriate for studies of macromolecules in high resolution suspension close to atomic level. After 50 years the techniques proposed and developed by this illustrious Venezuelan, are today validand of great importance since they have served as a basis for new areas of study, such as molecular pharmacology based on these biophysical principles. Dr. Fernandez Moran managed to predict that “at liquid Helium temperatures (-180 ° C) and high freezing speed, biological structures could be analyzed at high resolution and in a dynamic and hydrated state free of ice crystals.” Electronic Cryomicroscopy Transmission, (CryoTEM) is a biophysical method that is used to study biomolecules and frozen-hydrated molecular complexes at resolutions close to the atomic level. This technique brought with it the opening of new research in Molecular Pharmacology. Its application in the study and design of molecular antibodies has been successful in the formulation of new high-specific drugs without the production of the known side effects. Today, molecular pharmacology has made great progress in the possible production of vaccines in infectious contagious diseases that affect humanity.