Apoptosis by Substituted Tetrahydroquinolines in the Androgen-Independent Prostate Cancer Line PC-3

Authors

  • Adriana Mayora Central University of Venezuela (CUV)
  • Héctor Rojas Central University of Venezuela (CUV)
  • Perla Chirino Central University of Venezuela (CUV)
  • Felipe Sojo Institute for Advanced Studies (IFAS)
  • Vladimir Kouznetsov Industrial University of Santander, Colombia (IUS)
  • Juan De Sanctis Central University of Venezuela (CUV)
  • Francisco Arvelo Institute for Advanced Studies (IFAS)
  • Gustavo Benaim Central University of Venezuela (CUV)

Keywords:

Prostate cáncer, apoptosis, tetrahydroquinolines

Abstract

Cancer is a group of diseases characterized by uncontrolled cell growth and its pathophysiology includes aberrations in processes that intervene in the cell cycle, including the evasion of apoptosis. Androgen-independent (AI) prostate cancer (PC) cells are characterized by the evasion of apoptosis, so the ability of a compound to initiate apoptosis in tumor cells is an important strategy in the development of therapies. Substituted tetrahydroquinolines (THQs) make up a class of compounds with a wide range of biological activity, including as antitumor agents. This research studied the effect of 5 substituted THQs (JS43, JS56, JS79, JS87 and JS92) on the induction of apoptosis in the PC AI cell line PC-3.

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Published

2024-05-20

How to Cite

Mayora, A., Rojas, H., Chirino, P., Sojo, F., Kouznetsov, V., De Sanctis, J., Arvelo, F., & Benaim, G. (2024). Apoptosis by Substituted Tetrahydroquinolines in the Androgen-Independent Prostate Cancer Line PC-3. Observador Del Conocimiento, 2(4), 19–28. Retrieved from https://revistaoc.oncti.gob.ve/index.php/odc/article/view/513

Issue

Vol. 2 No. 4 (2014): abril

Section

Artículos

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This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.