Polymorphisms of the SLC11A1 Gene in Creole Goats. An Initial Study of Natural Resistance to Tuberculosis
Keywords:
Polymorphisms, SLC11A1 gene, resistance, paratuberculosisAbstract
Paratuberculosis is a chronic bacterial infection caused by Mycobacterium avium subspecies paratuberculosis (MAP), which mainly affects sheep, cattle and goats, characterized by progressive emaciation of the animal until its total deterioration. The control of paratuberculosis lies in measures of high economic cost and difficult implementation, for this reason alternatives are sought based on the genetic susceptibility of the host to the pathogen. The Slc11a1 gene encodes a cation transport protein located in the phagolysosome membrane of macrophages, which is actively involved in the suppression of bacterial infections.
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Awomoyi A. (2007). The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer? FEMS Immunology and Medical Microbiology. 49:324-329.
Barthel R.; J. Feng, J.; Piedrahita, D.; McMurray, J. Templeton y G. Adams. 2001. Stable transfection of bovine Nramp1 gene into murine RAW2647 cells: effects on Brucella abortus survival. Infect. Immun 69:3110-3119.
Caparelli R., Alfano, F., Amoroso, M., Borriello, G., Fenizia, D., Bianco, A., Roperto, S., Roperto F., Iannelli. D., 2007. Protective effect of the Nramp1BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis). Infect. Immun. 75:3089-3096.
Feng J., Li, Y., Hashad, M., Schurr, E., Gros, P., Adams G., Templeton. J., (1996). Bovine natural resistence associated macrophage protein 1 (Nramp 1) Gene. Genome research 6: 956-964.
Forbes J y P. Gros. 2001. Divalent-metal transport by NRAMP protein at the interface of host-pathogen interactions.Trends in Microbiology. 9:397-403.
Gasser R., Hu, M., Chilton, N., Campbell, B., Jex, A., Otranto, D., Cafarchia, C., Beveridge, I., Zhu. X., (2006). Single-strand conformation polymorphism (SSCP) for the analysis of genetic variation. Nature Protocols. Vol. 1 (6) 3121 – 3128.
Ibeagha-Awemu E., Kgwatalala, P., Ibeagha, A., y Zhao. X., 2008. A critical analysis of disease- ssociated DNA polymorphisms in the genes of cattle, goat, sheep and pig. Mammalian Genome. 19:226-245.
Korou L., Liandris, E., Gazouli M., Ikonomopoulos. J., (2010). Investigation of the association of the SLC11A1 gene with resistance/sensitivity of goats (Capra hircus) to paratuberculosis. Veterinary Microbiology. 144. (3-4). 353– 358.
Li X., Yang, Y., Zhou, F., Zhang, Y., Lu, H., Jiny, Q., Gao. L., (2011). SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis. PLoS ONE 6 (1): e15831. Doi:10.1371/ journal.pone.0015831
Liandris E., Gazouli, M., Ikonomopoulos, J., (2009). Characterization of the caprine (Capra hircus) SLC11A1 gene: innate resistance to paratuberculosis. Online J. Vet. Res. 13:41-52.
Martínez R., Toro, R., Montoya, F., Burbano M., Tobon, J., Gallego, J., Dunner S., Cañon. J., (2008). Bovine SLC11A1 3 UTR SSCP genotype evaluated by a macrophage in vitro killing assay employing a Brucella abortus strain. J. Anim. Breed. Genet. 125:271-279
Miller S., Dykes D., Polesky, H., (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids. Res. 16 (3):1215.
Reddacliff L., Beh, K., McGregor H., Whittington. R., (2005). A preliminary atudy of possible genetic influences on the susceptibility of sheep to Johne ́s disease. Aust. Vet. J. 83:435-441.
Vacca, G. Pazzola, M., Pisano, C., Carcangiu, V., Diaz, M., Nieddu, M., Robledo, R., Mezzanotte, R., Dettori, M., (2011). Chromosomal localisation and genetic variation of the SLC11A1 gene in goats (Capra hircus). The Veterinary Journal. 190:60 -65.
Vidal S., Pinner, E., Lepage, P., Gauthier, S., Gros. P., (1996). Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains. J. Immunol. 157:3559-3568.
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