Ethnobotanical use and acute toxicity study of bark extract Angostura trifoliata (willd) T.S. Elijah

Authors

  • Yenys Gimón Central University of Venezuela(CUoV)
  • Beatriz Guevara Central University of Venezuela(CUoV)
  • Trina Collman Central University of Venezuela(CUoV)

Keywords:

Alkaliodes, etrobotanical, toxic, macerated ethanol, Angostura bark

Abstract

The bark of Angostura trifoliata (Willd.) T.S Rutaceae has been used for therapeutic purposes in Venezuela. Objective: Determine the ethnobotanical use of this plant and study its toxic effects. Methodology: Using a protocol, previously validated in the La Florida, Anaco sector; A descriptive, analytical, cross-sectional study was carried out on a sample of 76 users of the bark of this plant, in popular markets of: Anaco. Mérida and Bolívar, to people over 18 years of age.

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References

Cambar, P.,"fabora, E., Fiallos, C., Alvarado, C., Cas­ co, E., Raudales, V. Vinelli, E y Lopez, C 1983. Efectos Neurofarmacológicos de los extractos acuosos de hojas de Synsepalum Dulcificum en ratones. Rev Medica Hondur 5(54): 85-92

Collet L Jacquernond, Hannedo uche S, Fouraste I., Moulis C. 2000 Novel quinoline alkaloid from trunk bark of Galipea officinali. Fitote­rapia 71: 605 - 606.

Darsow U, Drzezga AM, Frisch M, Munz F, Weilke F, Bartcnstein P, Schwaiger M, Ring. (2000 ) Processing of his tamine induced itch ill the human cerebral cortex: A correlation analy­sis with dermal reactions. J Invest Dermatol. (I 15): 1029 - 1033 .

Fernández M, Soares M, Batista J, Vieria P. 2007. Alkyl, Aryl, Alkylar quinoline, and related alkaloids related alkaloids. Alkaloids Chem Biol. 4 (64): 139-214.

Fondo Nacional de Ciencia y Tecnología. 2 0 2. Código de Bioética y Bioseguridad Segun­da Edición, Cap. 2. Caracas. Ministerio de Ciencia y Tecnología

Gama H, Aldo I, Sitoi F, Matola A, Barros H, Lunet N (2009) Factors associated with chloroquine induced pruritus during malaria treatment in Mozambican University students. Gae Sanil. 23 (4):306-310

Garcia M., Matias M. 2009. Modelos experimentales en Epilepsia Neurología. 25(3):181-188.

Gupta M. 1995. Plantas Medicinales lberoameri­canas. Programa lberoamericano de Ciencia.­

Drug Screeningand Evaluation of New Com ­ pounds in Animals. Year Book Medical Publishers, Inc USA: 36 -53.

Houghton P. Woldemariam T Z, Watanabe Y, Ya­tes M. 1999. Activity against Mycobacterium tuberculosis of alkaloid constituents of An­gostura bark, Galipea officinalis. Plant Med. 65(3 ):25-0 254.

Hokche 0 , Berry P.F. y Huber 0 . 2008. Catálogo de la flora Vascular de Venezuela. Instituto Botánico de Venezuela.

Irwin, S. 1964 . Animal and Clinical Pharmacol­ogy Techniques. In Drug Evaluation. Cap. 4: Drug Screening and Evaluation of New Compounds in Animals. Year Book. Medical Publishers, Inc. USA: 36-53.

Johnston G. 1978. Neuropharmacology of aminoacid inhibitory transmitters. Ann Rev. Phar­macol. Toxicol, J8: 269-289.

Lang CH. 1995. Inhibition of Central GABA , Re­ceptors Enhances Hepatic Glucose Produc­tion and Peripheral Glucose Uptake. Brain Res Bull. 37 (6 ): 611-616.

Lang CH. 1994. Inhibition of central GABA re­ceptors enhances hepatic glucose production and peripheral glucose uptake. J Neuroendocri. 6(4 ):443 -446.

Litchfield J and Wilcoxon F. 1949. A simplified method of evaluating dose-effect experiment, Pharmacol.9 6: 99 -115.

Narita K. Nishihara M, Takahashi YI 1994. Con­ comitant regulation of running activity and metabolic change by the vent remedial nucleus of the hypothalamus. Brain Res. 64 2:290 - 296

Nehlig A, Dube,Ce, Koning E. 2002. Status epilep­ticus induced by lithium-pilocarpine in the immaturerat does not change the long-term susceptibility to seizures. Epilepsy Res. Sl:

- 197

Nonogaki K, Iguchi A, Sakamoto N 1998. Bicucul­line methiodide influences the central ner­vous system to produce hyperglycemia in rats. Neuroendocrinol. 6:443-446.

Nowak M, Young A. and Mc Donald R. 1982. GABA and bicuculine ractions on mouse spinal cord and cortical neurons in cell culture. Brain

Rodríguez P. 1985 . Arbol de America del Sur. En Venezuela en Guayana y zonas adyacentes. Editorial Avila: 72.

Steyermark J, Berry P, Yatskievych K, and Holst B. 2 0 0 5. Flora of the Venezue la n Guayana. Edito­ rial Missouri Bottanical Garden Press. 9:6-7.

Uphot: J.C.Th. I968. Dictionary of economic plants. 2• ed. Cramer, Editorial, Lehre.

Vehsek L. 2009. Mode ls of Generalized Seizures in Freely Moving An imals. Elsevier: 775- 780

Vidal, I. 2009. Piloerección como efecto colateral de la dobutamina. Arq Bras Cardiol 92 (4): 283-285.

Published

2024-07-25

How to Cite

Gimón, Y., Guevara, B., & Collman, T. (2024). Ethnobotanical use and acute toxicity study of bark extract Angostura trifoliata (willd) T.S. Elijah. Observador Del Conocimiento, 2(1), 65–71. Retrieved from https://revistaoc.oncti.gob.ve/index.php/odc/article/view/665

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